What’s Wrong With Basing Your Life on a Lie?

As in the science fiction film ‘The Matrix,’ let’s say I discover that my familiar world, the whole of my life, has been a dream produced by an evil scientist. My body which has been asleep since birth awakes to a world reduced to a post-apocalyptic wasteland. A mysterious stranger offers me two pills. The blue pill will let me return to my comfortable world of illusion, eliminating all knowledge of the choice I have made. The red pill will allow me to remain awake to face the awful truth.

I would take the red pill, without hesitation. As a (armchair) philosopher, I feel obliged to say that. But what's so wrong with taking the blue pill? Taking the blue pill means choosing a life 'based on a lie'. But at least I will have the complete confidence that the deception will never be uncovered. I will never live to regret my decision.